임신과 분만에 쓰이는 약물

mifepristone

Medical termination of intrauterine pregnancy, through day 49 of pregnancy. Patients may need treatment with misoprostol and possibly surgery to complete therapy

합성 steroid로 progesterone의 blocking하는 효과

자궁근육의 수축으로 임신의 종결에 사용

progesterone이 없을때는 partial agonist로 작용한다.

약한 anti glucocorticoid , anti androgenic property를 가진다.

it blocks the feedback effect of cortisol on corticotropin secretion

Misoprostol

Misoprostol is a synthetic prostaglandin E₁ analog that replaces the protective prostaglandins consumed with prostaglandin-inhibiting therapies (eg, NSAIDs); has been shown to induce uterine contractions

Use

Prevention of NSAID-induced gastric ulcers; medical termination of pregnancy of ≤49 days (in conjunction with mifepristone)

Use - Unlabeled/Investigational

Cervical ripening and labor induction (except in women with prior cesarean delivery or major uterine surgery); fat malabsorption in cystic fibrosis